Hamzah Saman was born in Beirut, Lebanon and came to the U.S. when he was 15 years old. He is proud of his role as "Thaer" in the short film Beirut Hide and Seek (2010), which won Best Short Film at the Evolution International Film Festival in 2012 and received honorable mention at the Los Angeles International Film Festival. He was the second lead in the feature film Mobster (2013) as "Ido Ron", which is about the head of the Israeli mob and a Special Agent working undercover. Mobster won Best of Festival at the 2013 Indie Fest USA International Film Festival. Saman also had a role in the Short Film For the Birds (2014), which won Best Live Action Short Film at the 2014 Cleveland International Film Festival and won Special Jury Award at the 2014 USA Film Festival.

Saman also starred as "Inmate 093" in Tom Six's horror film trilogy, The Human Centipede III (Final Sequence) (2015). He played an Arab prisoner who becomes part of a 500-person centipede and shared an unforgettable scene with Eric Roberts. In addition, Saman worked as a voiceover artist on the films X-Men: Days of Future Past (2014) and Escape Plan (2013). Saman is one of the first online Arab American Casting Directors with over 20,000 members worldwo\ide. He worked as a Casting Associate on the documentary He Named Me Malala (2015) with the Oscar-winning director, Davis Gugenheim. Saman was also featured in Argo (2012) and served as a Casting Associate. Saman has been working to change the perception of Arab and Middle Eastern artists in Hollywood through his acting and casting work 2015